Research Articles

1. Jha V, Xiong B, Kumari T, Kim K, Wang J, Lee J, Brown G, Asquith N, Gallagher J, Asherman L, Lambert T, Bai Y, Du X, Min JK, Sah R, Razani B, Lee JM, Italiano JE, Cho J. A critical role for ERO1α in arterial thrombosis and ischemic stroke. Circ Res In press
2. Li J, Kumari T, Barazia A, Jha V, Jeong S, Olson A, Kim M, Lee BK, Manickam V, Song Z, Clemens R, Razani B, Kim J, Dinauer M, Cho J. Neutrophil DREAM promotes neutrophil recruitment in vascular inflammation. J Exp Med. 2022: 219(1):e20211083 (Commentary in J Exp Med 2022:219:e20212141)
3. Xu Z, Liang Y, Delaney MK, Zhang Y, Kim K, Li J, Bai Y, Cho J, Ushio-Fukai M, Cheng N, Du X. Shear and integrin outside-in signaling activates NADPH-oxidase 2 to promote platelet activation. Arterioscler Thromb Vasc Biol. 2021;41(5):1638-1653 PMCID: PMC8057529
4. Green RS, Naimi WA, Oliver LD, O’Bier N, Cho J, Conrad DH, Martin RK, Marconi RT, Carlyon JA. Binding of host cell surface protein disulfide isomerase by Anaplasma phagocytophilum Asp14 enables pathogen infection. mBio 2020;11(1):e03141-19 PMCID: PMC6989111
5. Li J, Jeong S, Xiong B, Tseng A, Mahon AB, Isaacman S, Cho J. Repurposing pyridoxamine for therapeutic intervention of intravascular cell-cell interactions in mouse models of sickle cell disease. Haematologica 2020;105(10):2407-2419 (Commentary in Haematologica 2020;105(10):2348-2350) PMCID: PMC7556679
6. Li J, Kim K, Jeong SY, Chiu J, Xiong B, Petukhov PA, Dai X, Li X, Andrews RK, Du X, Hogg PJ, Cho J. Platelet protein disulfide isomerase promotes glycoprotein Ibα-mediated platelet-neutrophil interactions under thromboinflammatory conditions. Circulation 2019;139(10):1300-1319 PMCID: PMC6464389
7. Lv Y, Kim K, Sheng Y, Cho J, Qian Z, Zhao YY, Hu G, Pan D, Malik AB, Hu G. YAP Controls Endothelial Activation 1 and Vascular Inflammation through TRAF6. Circ Res 2018;123(1):43-56 PMCID: PMC6014930
8. Tseng A, Kim K, Li J, Cho J. Myeloperoxidase negatively regulates neutrophil-endothelial cell interactions by impairing αMβ2 integrin function in sterile inflammation. Front Med 2018;5:134 PMCID: PMC5946029
9. Kim YM, Youn SW, Varadarajan S, Das A, Chandhri R, Grajal HC, Kweon J, Leanhart S, He L, Toth PT, Kitajewski J, Rehman J, Yoon Y, Cho J, Fukai T, Ushio-Fukai M. Redox Regulation of Mitochondrial Fission Protein Drp1 by Protein Disulfide Isomerase Limits Endothelial Senescence. Cell Rep 2018;23(12):3565-3578 PMCID: PMC6324937
10. Kim K, Tseng A, Barazia A, Italiano JE, Cho J. DREAM plays an important role in platelet activation and thrombogenesis. Blood 2017;129:209-225 PMCID: PMC5234218
11. Kim K, Li J, Barazia A, Tseng A, Youn SW, Abbadessa G, Yu Y, Schwartz B, Andrews RK, Gordeuk VR, Cho J. ARQ 092, an orally-available, selective AKT inhibitor, attenuates neutrophil-platelet interactions in sickle cell disease. Haematologica 2017;102:246-259 PMCID: PMC5286933
12. Delaney MK, Kim K, Estevez B, Xu Z, Stojanovic-Terpo A, Shen B, Ushio-Fukai M, Cho J, Du X. Differential roles of the NADPH-oxidase 1 and 2 in platelet activation and thrombosis. Arterioscler Thromb Vasc Biol. 2016;36:846-854 PMCID: PMC4850088
13. Huang X, Dai Z, Cai L, Sun K, Cho J, Albertine KH, Malik AB, Schraufnagel DE, Zhao YY. Endothelial p110γPI3K mediates endothelial regeneration and vascular repair after inflammatory vascular injury. Circulation 2016;133:1093-1103 PMCID: PMC4792690
14. Estevez B, Kim K, Delaney MK, Stojanovic-Terpo A, Shen B, Ruan C, Cho J, Ruggeri ZM, Du X. Signaling-mediated cooperativity between glycoprotein Ib-IX and protease-activated receptors in thrombin-induced platelet activation. Blood 2016;127:626-636 PMCID: PMC4742550
15. Chen GF, Sudhahar V, Youn SW, Das A, Cho J, Kamiya T, Urao N, McKinney R, Surenkhuu B, Hamakubo T, Iwanari H, Li S, Christman J, Shantikumar S, Angelini G, Emanueli C, Ushio-Fukai M, Fukai T. Copper Transport Protein Antioxidant-1 Promotes Inflammatory Neovascularization via Chaperone and Transcription Factor Function. Sci Rep 2015;5:14780 PMCID: PMC4594038
16. Barazia A, Li J, Kim K, Shabrani N, Cho J. Hydroxyurea with AKT2 inhibition decreases vaso-occlusive events in sickle cell disease mice. Blood 2015;126:2511-2517 (cover image) PMCID: PMC4661173
17. Kim K, Li J, Tseng A, Andrews RK, Cho J. NOX2 is critical for heterotypic neutrophil-platelet interactions during vascular inflammation. Blood 2015;126:1952-1964 PMCID: PMC4608242
18. Feng Q, Shabrani N, Thon JN, Huo H, Thiel A, Machlus KR, Kim K, Brooks J, Li F, Luo C, Kimbrel EA, Wang J, Kim KS, Italiano J, Cho J, Lu SJ, Lanza R. Scalable generation of universal platelets from human induced pluripotent stem cells. Stem Cell Reports 2014;3:817-831 PMCID: PMC4235139
19. Delaney MK, Liu J, Kim K, Shen B, Stojanovic-Terpo A, Zheng Y, Cho J, Du X. Agonist-induced platelet procoagulant activity requires shear and a Rac1-dependent signaling mechanism. Blood 2014;124:1957-1967 PMCID: PMC4168351
20. Wang Z, Li J, Cho J, Malik AB. Prevention of vascular inflammation by nanoparticle targeting of adherent neutrophils. Nat Nanotechnol 2014;9(3):204-210 PMCID: PMC4100792
21. Li J, Kim K, Hahm E, Molokie R, Hay N, Gordeuk VR, Du X, Cho J. Neutrophil AKT2 regulates heterotypic cell-cell interactions during vascular inflammation. J Clin Invest 2014;124:1483-1496 (Commentary in J Clin Invest 2014;124:1462-1465) PMCID: PMC3973084
22. Rusu L, Andreeva AV, Visintine DJ, Kim K, Stojanovic-Terpo A, Liu G, Bakhshi FR, Vogel SM, Chernaya O, Haberichter SL, Iwanari H, Kusano-Arai O, Takao H, Suzuki N, Kozasa T, Cho J, Du X, Minshall RD. G protein-dependent basal and evoked endothelial cell vWF secretion. Blood 2014;123: 442-450. PMCID: PMC3894496
23. Shen B, Zhao X, O’Brien KA, Stojanovic-Terpo A, Delaney MK, Kim K, Cho J, Lam SCT, Du X. A directional switch of integrin signaling and a new anti-thrombotic strategy. Nature 2013;503(7474): 131-135 PMCID: PMC3823815
24. Kim K, Hahm E, Li J, Holbrook LM, Sasikumar P, Stanley RG, Ushio-Fukai M, Gibbins JM, Cho J. Platelet protein disulfide isomerase is required for thrombus formation but not for hemostasis in mice. Blood 2013;122:1052-1061 PMCID: PMC3739031
25. Kim K, Barazia A, Cho J. Real-time imaging of heterotypic platelet-neutrophil interactions on the activated endothelium during vascular inflammation and thrombus formation in live mice. JoVE 2013;(74) PMCID: PMC3643153
26. Hahm E, Li J, Kim K, Huh S, Rogelj S, Cho J. Extracellular protein disulfide isomerase regulates ligand binding activity of αMβ2 integrin and neutrophil recruitment during vascular inflammation. Blood 2013;121:3789-3800 (Plenary Paper) (Commentary in Blood 2013;121:3779-3780) PMCID: PMC3650702
27. Cho J, Kennedy DR, Lin L, Huang M, Merrill-Skoloff G, Furie BC, Furie B. Protein disulfide isomerase capture during thrombus formation in vivo depends on the presence of β3 integrins. Blood 2012;120: 647-655 PMCID: PMC3401216
28. Lu SJ, Li F, Yin H, Feng Q, Kimbrel E, Hahm E, Thon J, Wang W, Italiano JE Jr, Cho J, Lanza R. Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice. Cell Res 2011;21:530-545 (Co-corresponding author) PMCID: PMC3193430
29. Barthel SR, Wiese GK, Cho J, Opperman MJ, Siddiqui J, Pienta KJ, Furie B, Dimitroff CJ. α1,3 fucosyltransferases are master regulators of prostate cancer cell trafficking. Proc Natl Acad Sci U S A. 2009;106:19491-19496 PMCID: PMC2780742
30. Cho J, Furie BC, Coughlin SR, Furie B. A critical role for extracellular protein disulfide isomerase during thrombus formation in mice. J Clin Invest 2008;118:1123-1131 PMCID: PMC2248441
31. Cho J, Mosher DF. Role of fibronectin assembly in platelet thrombus formation. J Thromb Haemost 2006; 4:1461-1469
32. Cho J, Mosher DF. Impact of fibronectin assembly on platelet thrombus formation in response to type I collagen and von Willebrand factor. Blood 2006;108:2229-2236 PMCID: PMC1895571
33. Cho J, Mosher DF. Characterization of fibronectin assembly by platelets adherent to adsorbed laminin-111. J Thromb Haemost 2006:4;943-951 (Commentary in J Thromb Haemost 2006;4:940-942)
34. Cho J, Mosher DF. Enhancement of thrombogenesis by plasma fibronectin crosslinked to fibrin and assembled in platelet thrombi. Blood 2006;107:3555-3563 (Commentary in Blood 2006;107:3419-3420) PMCID: PMC1457097
35. Cho J, Degen JL, Coller BS, Mosher DF. Fibrin but not adsorbed fibrinogen supports assembly of soluble fibronectin by spread platelets: Effects of the interaction of αIIbβ3 with the C-terminus of the fibrinogen γ-chain. J Biol Chem 2005;280:35490-35498
36. Cho J, Yun C, Seo H, Koga T, Dan T, Koo B, Kim H. The antithrombotic efficacy of AT-1459, a novel, direct thrombin inhibitor, in rat models of venous and arterial thrombosis. Thromb Haemost 2001;86: 1512-1520
37. Cho J, Seo H, Yun C, Koo B, Yoshida S, Koga T, Dan T, Kim H. In vitro and in vivo studies of AT-1362, a newly synthesized and orally active inhibitor of thrombin. Thromb Res 2000;100:97-107