Research Articles
1. Cho J, Seo H, Yun C, Koo B, Yoshida S, Koga T, Dan T, Kim H. In vitro and in vivo studies of AT-1362, a newly synthesized and orally active inhibitor of thrombin. Thromb Res 2000;100:97-107
2. Cho J, Yun C, Seo H, Koga T, Dan T, Koo B, Kim H. The antithrombotic efficacy of AT-1459, a novel, direct thrombin inhibitor, in rat models of venous and arterial thrombosis. Thromb Haemost 2001;86: 1512-1520
3. Cho J, Degen JL, Coller BS, Mosher DF. Fibrin but not adsorbed fibrinogen supports assembly of soluble fibronectin by spread platelets: Effects of the interaction of αIIbβ3 with the C-terminus of the fibrinogen γ-chain. J Biol Chem 2005;280:35490-35498
4. Cho J, Mosher DF. Enhancement of thrombogenesis by plasma fibronectin crosslinked to fibrin and assembled in platelet thrombi. Blood 2006;107:3555-3563 (Commentary in Blood 2006;107:3419-3420) PMCID: PMC1457097
5. Cho J, Mosher DF. Characterization of fibronectin assembly by platelets adherent to adsorbed laminin-111. J Thromb Haemost 2006:4;943-951 (Commentary in J Thromb Haemost 2006;4:940-942)
6. Cho J, Mosher DF. Impact of fibronectin assembly on platelet thrombus formation in response to type I collagen and von Willebrand factor. Blood 2006;108:2229-2236 PMCID: PMC1895571
7. Cho J, Mosher DF. Role of fibronectin assembly in platelet thrombus formation. J Thromb Haemost 2006; 4:1461-1469
8. Cho J, Furie BC, Coughlin SR, Furie B. A critical role for extracellular protein disulfide isomerase during thrombus formation in mice. J Clin Invest 2008;118:1123-1131 PMCID: PMC2248441
9. Barthel SR, Wiese GK, Cho J, Opperman MJ, Siddiqui J, Pienta KJ, Furie B, Dimitroff CJ. α1,3 fucosyltransferases are master regulators of prostate cancer cell trafficking. Proc Natl Acad Sci U S A. 2009;106:19491-19496 PMCID: PMC2780742
10. Lu SJ, Li F, Yin H, Feng Q, Kimbrel E, Hahm E, Thon J, Wang W, Italiano JE Jr, Cho J,* Lanza R.* Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice. Cell Res 2011;21:530-545 (*:Co-corresponding author) PMCID: PMC3193430
11. Cho J, Kennedy DR, Lin L, Huang M, Merrill-Skoloff G, Furie BC, Furie B. Protein disulfide isomerase capture during thrombus formation in vivo depends on the presence of β3 integrins. Blood 2012;120: 647-655 PMCID: PMC3401216
12. Hahm E, Li J, Kim K, Huh S, Rogelj S, Cho J. Extracellular protein disulfide isomerase regulates ligand binding activity of αMβ2 integrin and neutrophil recruitment during vascular inflammation. Blood 2013;121:3789-3800 (Plenary Paper) (Commentary in Blood 2013;121:3779-3780) PMCID: PMC3650702
13. Kim K, Barazia A, Cho J. Real-time imaging of heterotypic platelet-neutrophil interactions on the activated endothelium during vascular inflammation and thrombus formation in live mice. JoVE 2013;(74) PMCID: PMC3643153
14. Kim K, Hahm E, Li J, Holbrook LM, Sasikumar P, Stanley RG, Ushio-Fukai M, Gibbins JM, Cho J. Platelet protein disulfide isomerase is required for thrombus formation but not for hemostasis in mice. Blood 2013;122:1052-1061 PMCID: PMC3739031
15. Shen B, Zhao X, O’Brien KA, Stojanovic-Terpo A, Delaney MK, Kim K, Cho J, Lam SCT, Du X. A directional switch of integrin signaling and a new anti-thrombotic strategy. Nature 2013;503(7474): 131-135 PMCID: PMC3823815
16. Rusu L, Andreeva AV, Visintine DJ, Kim K, Stojanovic-Terpo A, Liu G, Bakhshi FR, Vogel SM, Chernaya O, Haberichter SL, Iwanari H, Kusano-Arai O, Takao H, Suzuki N, Kozasa T, Cho J, Du X, Minshall RD. G protein-dependent basal and evoked endothelial cell vWF secretion. Blood 2014;123: 442-450. PMCID: PMC3894496
17. Li J, Kim K, Hahm E, Molokie R, Hay N, Gordeuk VR, Du X, Cho J. Neutrophil AKT2 regulates heterotypic cell-cell interactions during vascular inflammation. J Clin Invest 2014;124:1483-1496 (Commentary in J Clin Invest 2014;124:1462-1465) PMCID: PMC3973084
18. Wang Z, Li J, Cho J, Malik AB. Prevention of vascular inflammation by nanoparticle targeting of adherent neutrophils. Nat Nanotechnol 2014;9(3):204-210 PMCID: PMC4100792
19. Delaney MK, Liu J, Kim K, Shen B, Stojanovic-Terpo A, Zheng Y, Cho J, Du X. Agonist-induced platelet procoagulant activity requires shear and a Rac1-dependent signaling mechanism. Blood 2014;124:1957-1967 PMCID: PMC4168351
20. Feng Q, Shabrani N, Thon JN, Huo H, Thiel A, Machlus KR, Kim K, Brooks J, Li F, Luo C, Kimbrel EA, Wang J, Kim KS, Italiano J, Cho J, Lu SJ, Lanza R. Scalable generation of universal platelets from human induced pluripotent stem cells. Stem Cell Reports 2014;3:817-831 PMCID: PMC4235139
21. Kim K, Li J, Tseng A, Andrews RK, Cho J. NOX2 is critical for heterotypic neutrophil-platelet interactions during vascular inflammation. Blood 2015;126:1952-1964 PMCID: PMC4608242
22. Barazia A, Li J, Kim K, Shabrani N, Cho J. Hydroxyurea with AKT2 inhibition decreases vaso-occlusive events in sickle cell disease mice. Blood 2015;126:2511-2517 (cover image) PMCID: PMC4661173
23. Chen GF, Sudhahar V, Youn SW, Das A, Cho J, Kamiya T, Urao N, McKinney R, Surenkhuu B, Hamakubo T, Iwanari H, Li S, Christman J, Shantikumar S, Angelini G, Emanueli C, Ushio-Fukai M, Fukai T. Copper Transport Protein Antioxidant-1 Promotes Inflammatory Neovascularization via Chaperone and Transcription Factor Function. Sci Rep 2015;5:14780 PMCID: PMC4594038
24. Estevez B, Kim K, Delaney MK, Stojanovic-Terpo A, Shen B, Ruan C, Cho J, Ruggeri ZM, Du X. Signaling-mediated cooperativity between glycoprotein Ib-IX and protease-activated receptors in thrombin-induced platelet activation. Blood 2016;127:626-636 PMCID: PMC4742550
25. Huang X, Dai Z, Cai L, Sun K, Cho J, Albertine KH, Malik AB, Schraufnagel DE, Zhao YY. Endothelial p110γPI3K mediates endothelial regeneration and vascular repair after inflammatory vascular injury. Circulation 2016;133:1093-1103 PMCID: PMC4792690
26. Delaney MK, Kim K, Estevez B, Xu Z, Stojanovic-Terpo A, Shen B, Ushio-Fukai M, Cho J, Du X. Differential roles of the NADPH-oxidase 1 and 2 in platelet activation and thrombosis. Arterioscler Thromb Vasc Biol. 2016;36:846-854 PMCID: PMC4850088
27. Kim K, Li J, Barazia A, Tseng A, Youn SW, Abbadessa G, Yu Y, Schwartz B, Andrews RK, Gordeuk VR, Cho J. ARQ 092, an orally-available, selective AKT inhibitor, attenuates neutrophil-platelet interactions in sickle cell disease. Haematologica 2017;102:246-259 PMCID: PMC5286933
28. Kim K, Tseng A, Barazia A, Italiano JE, Cho J. DREAM plays an important role in platelet activation and thrombogenesis. Blood 2017;129:209-225 PMCID: PMC5234218
29. Kim YM, Youn SW, Varadarajan S, Das A, Chandhri R, Grajal HC, Kweon J, Leanhart S, He L, Toth PT, Kitajewski J, Rehman J, Yoon Y, Cho J, Fukai T, Ushio-Fukai M. Redox Regulation of Mitochondrial Fission Protein Drp1 by Protein Disulfide Isomerase Limits Endothelial Senescence. Cell Rep 2018;23(12):3565-3578 PMCID: PMC6324937
30. Tseng A, Kim K, Li J, Cho J. Myeloperoxidase negatively regulates neutrophil-endothelial cell interactions by impairing αMβ2 integrin function in sterile inflammation. Front Med 2018;5:134
PMCID: PMC5946029
31. Lv Y, Kim K, Sheng Y, Cho J, Qian Z, Zhao YY, Hu G, Pan D, Malik AB, Hu G. YAP Controls Endothelial Activation 1 and Vascular Inflammation through TRAF6. Circ Res 2018;123(1):43-56
PMCID: PMC6014930
32. Li J, Kim K, Jeong SY, Chiu J, Xiong B, Petukhov PA, Dai X, Li X, Andrews RK, Du X, Hogg PJ, Cho J. Platelet protein disulfide isomerase promotes glycoprotein Ibα-mediated platelet-neutrophil interactions under thromboinflammatory conditions. Circulation 2019;139(10):1300-1319 PMCID: PMC6464389
33. Li J, Jeong S, Xiong B, Tseng A, Mahon AB, Isaacman S, Cho J. Repurposing pyridoxamine for therapeutic intervention of intravascular cell-cell interactions in mouse models of sickle cell disease. Haematologica 2020;105(10):2407-2419 (Commentary in Haematologica 2020;105(10):2348-2350)
PMCID: PMC7556679
34. Green RS, Naimi WA, Oliver LD, O’Bier N, Cho J, Conrad DH, Martin RK, Marconi RT, Carlyon JA. Binding of host cell surface protein disulfide isomerase by Anaplasma phagocytophilum Asp14 enables pathogen infection. mBio 2020;11(1):e03141-19 PMCID: PMC6989111
35. Xu Z, Liang Y, Delaney MK, Zhang Y, Kim K, Li J, Bai Y, Cho J, Ushio-Fukai M, Cheng N, Du X. Shear and integrin outside-in signaling activates NADPH-oxidase 2 to promote platelet activation. Arterioscler Thromb Vasc Biol. 2021;41(5):1638-1653 PMCID: PMC8057529
36. Li J, Kumari T, Barazia A, Jha V, Jeong S, Olson A, Kim M, Lee BK, Manickam V, Song Z, Clemens R, Razani B, Kim J, Dinauer M, Cho J. Neutrophil DREAM promotes neutrophil recruitment in vascular inflammation. J Exp Med. 2022: 219(1):e20211083 (Commentary in J Exp Med 2022:219:e20212141) PMCID: PMC8719643
37. Zhang X, Misra SK, Moitra P, Zhang X, Jeong SJ, Stitham J, Rodriguez-Velez A, Park A, Yeh YS, Gillanders WE, Fan D, Diwan A, Cho J, Epelman S, Lodhi IJ, Pan D, Razani B. Use of acidic nanoparticles to rescue macrophage lysosomal dysfunction in atherosclerosis. Autophagy 2023;19(3): 886-903. doi: 10.1080/15548627.2022.2108252 PMCID: PMC9980706
38. Nagarkoti S, Kim YM, Ash D, Das A, Vitriol E, Read TA, Youn SW, Varadarajan S, McMenamin M, Hou Y, Boatwright H, Caldwell R, Essex DW, Cho J, Fukai T, Ushio-Fukai M. Protein disulfide isomerase A1 as a novel redox sensor in VEGFR2 signaling and angiogenesis. Angiogenesis 2023; 26(1):77-96 PMCID: PMC9918675
39. Cho MJ, Lee DG, Lee JW, Hwang B, Yoon SJ, Lee SJ, Park YJ, Park SH, Lee HG, Kim YH, Lee CH, Lee J, Lee NK, Han TS, Cho HS, Moon JH, Lee GS, Bae KH, Hwang GS, Lee SH, Chung SJ, Shim S, Cho J, Oh GT, Kwon YG, Park JG, Min JK. Endothelial PTP4A1 mitigates vascular inflammation via USF1/A20 axis-mediated NF-κB inactivation. Cardiovasc Res 2023;119(5):1265-1278
40. Jha V, Xiong B, Kumari T, Kim K, Wang J, Lee J, Brown G, Asquith N, Gallagher J, Asherman L, Lambert T, Bai Y, Du X, Min JK, Sah R, Razani B, Lee JM, Italiano JE, Cho J. A critical role for ERO1α in arterial thrombosis and ischemic stroke. Circ Res 2023;132(11):e206-e222 PMCID: PMC10213138
41. Zhang X, Evans TD, Chen S, Sergin I, Stitham J, Jeong SJ, Rodriguez-Velez A, Yeh YS, Park A, Jung IH, Diwan A, Schilling JD, Rom O, Yurdagul A, Epelman S, Cho J, Lodhi IJ, Mittendorfer B, Razani B. Loss of macrophage mTORC2 drives atherosclerosis via FoxO1 and IL-1β signaling. Circ Res 2023; 133(3):200-219
42. Subramani K, Bander J, Chen X, Suárez-Fariñas M, Venkatesan T, Subrahmanian S, Varshney R,
Kini A, Sharma S, Rifkin DB, Cho J, Coller BS, Ahamed J. Evidence that anemia accelerates aortic stenosis progression via shear-induced TGF-β1 activation: Heyde’s syndrome comes full circle. JACC: Basic to Translational Science. 2023;9(2):185-199
43. Zhang X, Kapoor D, Jeong SJ, Fappi A, Stitham J, Shabrish V, Sergin I, Yousif E, Rodriguez-Velez A, Yeh YS, Park A, Yurdagul Jr. A, Rom O, Epelman S, Schilling JD, Sardiello M, Diwan A, Cho J, Stitziel NO, Javaheri A, Lodhi IJ, Mittendorfer B, Razani B. Identification of a leucine-mediated threshold effect governing macrophage mTOR signaling and cardiovascular risk. Nat Metabol. 2024;6(2):359-377
44. Chen Z, Wang S, Pottekat A, Duffey A, Jang I, Chang BH, Cho J, Finck BN, Davidson NO, Kaufman RJ. Conditional hepatocyte ablation of PDIA1/P4HB uncovers its indispensable roles for both APOB and MTTP folding to support VLDL secretion. Mol Metabol. 2024;80:101874.
45. Lee J, Balzraine B, Schweizer A, Kuzmanova V, Gwack Y, Razani B, Lee JM, Mosher DF, Cho J. Neutrophil CRACR2A promotes neutrophil recruitment in sterile inflammation and ischemic stroke. Circulation In press.
Invited Reviews/Commentaries
1. Smyth SS et al. 2009 Platelet functions beyond hemostasis. J Thromb Haemost. 2009;11:1759-1766
2. Wang Z, Tiruppathi C, Cho J, Minshall RD, Malik AB. Targeting of nanoparticle-complexed drugs across the vascular endothelial barrier via caveolae. IUBMB Life 2011;63:659-667 PMCID: PMC3142311
3. Cho J. Protein disulfide isomerase in thrombosis and vascular inflammation. J Thromb Haemost 2013;11:2084-2091 PMCID: PMC4076787
4. Li J, Kim K, Barazia A, Tseng A, Cho J. Platelet-neutrophil interactions under thromboinflammatory conditions. Cell Mol Life Sci. 2015:72(14):2627-2643 PMCID: PMC4480154
5. Cho J. A paradigm shift in platelet transfusion therapy. Blood 2015:125:3523-3525 PMCID: PMC4458795
6. Cho J. DREAM as a novel target for anti-thrombotic agents. Pharmacol Res 2017;117:283-287 PMCID: PMC5316308
7. Li J, Cho J. Protein kinase Bβ-NADPH oxidase 2 signaling in thromboinflammation. Curr Opin Hematol 2017;24:460-466 PMCID: PMC5847267
8. Xiong B, Jha V, Min JK, Cho J. Protein disulfide isomerase in cardiovascular disease. Exp Mol Med 2020;52(3):390-399 PMCID: PMC7156431
9. Jha V, Kumari T, Manickam V, Assar Z, Olson KL, Min JK, Cho J. ERO1-PDI redox signaling in health and diseases. Antioxid Red Signal 2021;35(13):1093-1115 PMCID: PMC8817699
10. Lee J, Jin BR, Cho J. Spatiotemporal regulation of neutrophil heterogeneity in health and disease. Hum Mol Genet Accepted